Cinnamomum zeylanicum, a widely used spice and flavor, is used in the treatment andprevention of many diseases. In the current study, Balb/c mice were pretreated withcinnamon bark aqueous extract (200 mg/kg/day i.g.) 14 days prior to intragastricallyadminister single toxic dose of acetaminophen (200 mg/kg). Blood samples werecollected for analysis of biochemical and oxidative stress parameters and liver and kidneysamples were collected for histopathological analysis. The results indicate that cinnamonaqueous extract exhibit a highly significant preventive potential by ameliorating APAP-induced elevated levels of serum alanine aminotransferase, aspartate aminotransferase,creatinine, urea and macroscopic and histological alterations in liver and kidney.Moreover, significant increase in total oxidant status and decrease in total antioxidantcapacity accompanied by APAP exposure, were restored by cinnamon pretreatment. Wefound that prior administration of cinnamon prevented the toxic changes induced byacetaminophen as confirmed by histopathological examination, more possibly owing toits antioxidant potential. In conclusion, the pretreatment with cinnamon providepotential therapeutic applications in acute liver and kidney injury induced by APAP inexperimental animal model and it could have therapeutic potential in oxidative stressassociated diseases.

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