BIO-TFF01 Small Tangential flow filter membrane ultrafiltration system

Tangential flow filter, also known as cross flow filter, refers to the liquid flow direction and filter direction perpendicular to the filter form.

PRODUCT MODEL: BIO-TFF01 Categories: ,

Small tangential flow

membrane ultrafiltration system

TFF Overview

Understanding tangential flow membrane ultrafiltration systems

Brief Introduction of Tangential flow filter (TFF)

Tangential flow filter (TFF), also known as cross flow filter (CFF), refers to the liquid flow direction and filter direction perpendicular to the filter form. Liquid flow creates a shear force on the surface of the filter media, reducing the stacking of the cake layer or gel layer, thus ensuring a stable filtration rate.

According to the trapped particles or molecular size can be divided into microfiltration MF, ultrafiltration UF, nanofiltration NF and reverse osmosis RO. TFF technology is currently widely used in pharmaceutical, biological, chemical, food and beverage and environmental protection industries.

System Overview

The small tangential flow ultrafiltration system is a set of TFF devices developed by Labgeni for laboratory users. It is mainly applied to TFF research of small scale or pilot scale in laboratory. The system uses imported original box-type flat film package, can achieve microfiltration, ultrafiltration, to meet the needs of laboratory diversification.

System applications

  • Cell collection, cell fluid clarification and filtration, recovery of antibodies or recombinant proteins
  • Concentration and desalination of proteins, peptides or nucleic acids (DNA / RNA / oligonucleotides)
  • Remove heat source or impurity molecules in the water, buffer, medium solution, equal volume of continuous dialysis
  • System Features:
  • Sample recovery rate is extremely high, and efficiently ensure protein activity
  • Filtration speed is stable, can be continuous cycle of filtration, the film surface does not form a gel layer
  • Easy to linear amplification, the maximum reduction time and cost from small scale preparation to large-scale production
  • Universal stainless steel fixture, matching the major brands of imported original box-type film package, which can be installed  1 to 3 pieces at the same time
  • Integrated design, easy to operate, according to different needs to choose the appropriate film fixture, peristaltic pump and film package
  • Stainless steel stent + raw material tank, siphon feeding, easy  for  laboratory aseptic continuous operation

System Applications

  • Cell collection, cell fluid clarification and filtration, recovery of antibodies or recombinant proteins
  • Concentration and desalination of proteins, peptides or nucleic acids (DNA / RNA / oligonucleotides)
  • Remove heat source or impurity molecules in the water, buffer, medium solution, equal volume of continuous dialysis
  • System Features:
  • Sample recovery rate is extremely high, and efficiently ensure protein activity
  • Filtration speed is stable, can be continuous cycle of filtration, the film surface does not form a gel layer
  • Easy to linear amplification, the maximum reduction time and cost from small scale preparation to large-scale production
  • Universal stainless steel fixture, matching the major brands of imported original box-type film package, which can be installed  1 to 3 pieces at the same time
  • Integrated design, easy to operate, according to different needs to choose the appropriate film fixture, peristaltic pump and film package
  • Stainless steel stent + raw material tank, siphon feeding, easy  for  laboratory aseptic continuous operation

BIO-TFF01 System

It is suitable for small-scale TFF research in biological laboratories, such as biological separation, material concentration and protein solution purification.  Small size, exquisite, easy to disassemble.

BIO-TFF01 Basic Information

  • Model: BIO-TFF01
  • Process capacity: 0.1 ~ 20L/H
  • Membrane form: 1~3 blocks,  0.1㎡imported box type flat membrane
  • Power unit: Precision peristaltic pump 220V, Maximum flow 2L/MIN
  • Raw material tank: Material AISI 316L, volume 2L
BIO-TFF-series Small tangential flow membrane ultrafiltration system

BIO-TFF05 System

  • Model: BIO-TFF05
  • Suitable for laboratory small-scale TFF studies
  • Biological separation, material concentration and protein purification
  • It is designed and manufactured by medical grade sanitary standard. It is small, exquisite and easy to assemble and disassemble
BIO-TFF-series Small tangential flow membrane ultrafiltration system

BIO-TFF05 Basic Information

  • Model: BIO-TFF05
  • Membrane form: 1 to 3 imported original box-type flat membranes of 0.5 square meters
  • Membrane material: Biomax (polyethersulfone), PLC (modified cellulose), PVDF (polyvinylidene fluoride)
  • Process capacity: 30 ~ 90L/H
  • Power unit: Precision original peristaltic pump 220V, maximum flow 9L/min
  • Raw material tank: material AISI 316L, volume 3.5L

Stainless steel fixture

  • Material AISI 316L
  • 2 in 2 out sanitary quick interface with mirror polishing internal surface and sand blasting outside surface
  • Fit 0.1 ㎡ imported box type flat membrane, optional brand Millpore, Sartorius and PALL

Power unit

  • LONGER peristaltic pump with reliable quality
  • Maximum flow: 2L/MIN,Maximum pressure: 0.3Mpa
  • Control: Start and stop control, direction control, speed control (0-5V, 0-10V, 0-, 10KHZ are optional)

Stainless steel bracket + raw material tank

  • Material AISI 316L
  • Sartorius Outlet Filter
  • Siphon feeding, easy lab aseptic continuous operation
  • Tank volume: 1L, 2L, 3.5L, 5L, 10L, can be customized

Flat membrane packs

  • Filtration area: 0.1㎡, Ultrafiltration / microfiltration is optional
  • Membrane material: Biomax, PLC  (modified cellulose), PVDF  (polyvinylidene fluoride)
  • Optional brand: Millpore, Sartorius, PALL

 

Membrane material Molecular weight cut-off (kD) most suitable molecular retention range
>99% (KD)
Biomax-5 5 12-25 (growth factor, hormone)
Biomax-8 8 25-50 (growth factor, hormone)
Biomax-10 10 50-100 (growth factor, hormone)
Biomax-30 30 100-140 (enzyme)
Biomax-50 50 140-300 (lgGs)
Biomax-100 100 300-500 (parvovirus, antigen)
Biomax-300 300 > 500 (lgMs, big virus)
Biomax-500 500 > 0.3um (colloid, granules)
Biomax-1000 1000 > 0.3um (colloid, granules)
PLCCC 5 8-18 (proinsulin, hematopoietic factor)
PLCGC 10 18-60 (hemoglobin, enzyme)
PLCTK 30 60-200 (monoclonal antibody)
PLCHK 100 200-500 (parvovirus, viral antigen)
PLCMK 300 > 500 (lgMs, big virus)
PLCXK 1000 > 0.3um (colloid, granules)
PVDF (Microfiltration) 0.1um/0.22um /0.45um/0.65um Large diameter of the bacteria, particles

Specification parameter

Model BIO-TFF01 BIO-TFF05

Power unit

  • Precision peristaltic pump 220V
  • Maximum flow 2L/MIN
  • Seamless replacement with four plunger diaphragm pump
  • Speed range 1-600RPM
  • Precision peristaltic pump 220V
  • Maximum flow 2L/MIN
  • Seamless replacement with four plunger diaphragm pump
  • Speed range 1-600RPM

Membrane element

  • Imported box type flat membrane, with an area of 0.1 square meters, can install 1~3 blocks
  • Imported box type flat membrane, with an area of 0.5 square meters, can install 1~3 blocks

Process capacity 

  • 0.1 ~ 20L/H
  • 30 ~ 90L/H

Stainless steel fixture        

  • Material AISI 316L
  • sanitary quick interface with mirror polishing internal surface and sand blasting outside surface
  • fit all brands of membrane packs
  • Material AISI 316L
  • sanitary quick interface with mirror polishing internal surface and sand blasting outside surface
  • fit all brands of membrane packs

Pressure gauge

  • Sanitary diaphragm pressure gauge, range 0 ~ 4Mpa, anti-shaking pointer
  • Sanitary diaphragm pressure gauge, range 0 ~ 4Mpa, anti-shaking pointer

Stainless steel bracket

  • Material AISI 316L, sand blasting outside surface
  • Material AISI 316L, sand blasting outside surface

Raw material tank

  • Material AISI 316L, volume 2L, Sartorius outlet filter
  • Material AISI 316L, volume 3.5L, Sartorius outlet filter

 

Optional items

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